Endocrine Abstracts

Introduction: The mixed tumor which secretes an excess of both GH and TSH causing acromegaly and hyperthyroidism is rare. The main problem is the late diagnosis, especially in men, even 10 years after the occurrence of the first symptoms.Case report: A 53-year-old men, was admitted to the our department, with complaints of excessive sweating and enlargement of the hands. His medical history included arterial hypertension. Past medical history revealed th...

Introduction: In the testicular adrenal rest tumor (TART) syndrome, doctors think before all to preserve fertility and oncological risk. Meanwhile, for the patient are relevant primarily those disorders that hinder him daily functioning and affect the quality of life. Because of it, we would like to introduce our patient with cognitive impairment.Case report: A 20-year-old male, working in the factory, came to an endocrinologist at the request of his mot...

A 25-year-old lady with poorly controlled type I diabetes presented acutely with vomiting, peripheral oedema and abdominal distention.She was diagnosed with type I diabetes at the age of 12 and her glycaemic control has always been suboptimal predominantly due to poor compliance with the treatment. She had had numerous admissions with diabetic ketoacidosis in the past.On examination a tender hepatomegaly was noted. The investigatio...

This lady with a background of schizophrenia and depression, on long term lithium therapy, initially presented in 2002, at the age of 53, with acute renal failure and symptoms of lithium toxicity secondary to sepsis. Lithium level measured at the time was 2.5 mEq/l and her creatinine 314 μmol/l. She was normocalcaemic on admission. The patient was hospitalized on ICU and the treatment included ventilation, haemofiltration and inotropic support.On 10...

Aim: The aim of the study was to evaluate the birth weight of children born to women with AITD compared to with those born to women without AITD.Material and methods: The study included 596 pregnant women and their children in 2007–2015. The patients were divided into two groups. The first (group A) consisted of 191 pregnant women with chronic autoimmune thyroiditis and their children, while the second (group B) consisted of 405 pregnant women witho...

Introduction: Polycystic ovary syndrome (PCOS) is characterized by menstrual disorders, hyperandrogenism and polycystic ovaries on ultrasonography. This hormonal disorder is also strongly associated with insulin resistance. The diagnosis of PCOS can be established after the exclusion of other causes of mentioned symptoms, such as non-classic congenital adrenal hyperplasia (NCAH). To date, several studies suggest the increased serum concentration of 17-hydroxyprogesterone (17-O...

Introduction: Parathyroid carcinoma is a rare endocrine malignancy accounting for <1% of all cases of hyperparathyroidism. Diagnosis and treatment is still difficult.Case report: A 32-year-old women was admitted to the hospital because of mental status changes, polyuria, polydipsia, musculoskeletal pain and weight loss (34 kg during last year). She had history of nephrolithiasis, pancreatitis, cholelithiasis, peptic ulcer disease, osteoporosis and di...

Resistin is a recently discovered 12.5 kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes and plays important role in the development of insulin resistance and obesity. Recently, many investigators have linked resistin to reproductive function. Resistin expression was observed in bovine and rat ovaries and showed that resistin modulate granulosa cells function such as steroidogenesis and proliferation, in basal state or in response to IGF-I in vit...

Resistin, a new 12.5 kDa cysteine-rich protein, which is specifically secreted by adipocytes and describe as a potential link between obesity and insulin resistance. Recently, resistin and PPARs receptors was found in reproductive tissue such as ovary and it was found that resistin modulate ovarian follicle function. Additionally, thiazolidinediones, such as rosiglitazone, a synthetic agonist of PPAR-γ down-regulated resistin expression in rodents. The aim of the study wa...

Polycystic ovary syndrome (PCOS) is heterogeneous disorder, where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. Insulin resistance is associated with the so-called metabolic inflexibility i.e. an impaired switch from lipid to glucose in response to insulin. The aim of the present study was to estimate glucose and lipid oxidation, metabolic flexibility and non-oxidative glucose metabolism in lean and obese PCOS patients.<p...